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Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices

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However, attenuated signaling or cellular tolerance is the sum of multiple processes including: receptor desensitization, receptor resensitization, receptor internalization (recycling or downregulation), de novo receptor synthesis, and Golgi stability, as well as receptor trafficking to the cell membrane (externalization)

Similar results were observed by Schneeweiss et al., who analyzed more than 240,000 patients with chronic inflammatory skin disease and nearly 2.4 million controls and found that the risk for ulcerative colitis and Crohns disease was significantly higher in patients with septic sweat glands and risk for Crohns disease was significantly higher in patients with psoriasis (Schneeweiss et al., 2022)