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Prior to any procedures, animals are anesthetized using a combination of xylazine (10 mg/kg) and ketamine (90 mg/kg) for up to one hour via the intraperitoneal route
Culhane KJ, Liu Y, Cai Y, Yan EC
Do not recap the needle to prevent accidental needle-stick injuries
Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence
