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When deficiency is diagnosed, lifelong B replacement is often required (especially in pernicious anemia)

Oxidative stress, therefore, drives the pathology of COPD and may increase disease progression, amplify exacerbations, and increase comorbidities through systemic oxidative stress

The body is equipped with an antioxidant defense system that guards against oxidative damage caused by these reactive oxidants and plays a major role in protecting cells from oxidative stress and damage

Nat Rev Drug Discov 7 , 489503, (2008)
