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The kinetic equilibrium of GSH with its oxidized form, GSSG, can provide a functional biomarker for tissue response to therapy involving reactive molecular species, reflecting the cells response to oxidative stress 6

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Folate (vitamin B9), a carrier of one-carbon units, and other B vitamins, such as B6 and B12, take part widely in one-carbon metabolism, which is requisite for DNA biosynthesis and methylation (51)

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