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FIGURE 1 Glutathione Metabolism Is Related to Ferroptosis System Xc is a Na + -dependent cysteine-glutamate antiporter located in the membrane that is composed of SLC3A2 and SLC7A11 (xCT) and responsible for the exchange of intracellular glutamate for extracellular cystine at a 1:1 ratio ( via the GSH synthesis process ( de novo GSH synthesis ( , which is not regulated by ATP, is activated by high concentrations of intracellular glutamate

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Nano-sized platinum as a mimic of uricase catalyzing the oxidative degradation of uric acid