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However, tumor cells can remodel TME by several means, including increased immunosuppressive population, reduced infiltration of tumor-inhibitory immune cells, reduced presentation of tumor antigens on MHC molecules, and more, allowing them to evade the immune system ( Figure 3F )

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For example, flavoring compounds and humectants used in vaping products, although generally recognized as safe for oral consumption, can cause adverse effects when inhaled, especially following heated aerosolization and subsequent degradation/oxidation