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Here, we report the results of a first-in-human phase 1 double-blind, placebo-controlled study (ClinicalTrials.gov ID: NCT02834442) that evaluated the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of single and multiple ascending oral doses of dersimelagon in healthy participants, including effects of sex, age, and race on the PK profile of dersimelagon

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