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Probability (p) 0.05 was considered as significant

doi: 10.1136/gutjnl-2021-326789 23 DimbaN

Microglia play a crucial role in orchestrating this phenotypic shift: upon activation, they release inflammatory mediators such as IL-1, TNF- and C1q, which induce a pro-inflammatory reactive astrocyte phenotype (often termed A1-like or neurotoxic reactive state) (Zhao et al., 2024

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