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Despite hundreds of studies, it is challenging to specify well-defined and described substances that could contribute to improving cognitive abilities in sports

Central to this concept linking neural and systemic functions is the concept of allostasis (adaptation) and allostatic load/overload (pathophysiology) [6] that emphasizes the role of endogenous mediators for adaptation in contributing to pathologies, including MDD, when activated persistently or dysregulated under circumstances of toxic stress and health-damaging behaviors (poor diet, excessive alcohol consumption, sleep deprivation and circadian disruption)

Forty-seven CAD patients were enrolled in the study

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