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Description
This transfer requires enzymes and transporters that accumulate carnitine within the cell (OCTN2 carnitine transporter), conjugate it with long chain fatty acids (carnitine palmitoyl transferase 1, CPT1), transfer the acylcarnitine across the inner plasma membrane (carnitine-acylcarnitine translocase, CACT), and conjugate the fatty acid back to Coenzyme A for subsequent beta oxidation (carnitine palmitoyl transferase 2, CPT2)

This last result in particular provides further evidence regarding the fact that a protein administered with our method is able to successfully diffuse from the guts to the different tissues of the animal in its native and functional state
In POMC neurons, the POMC gene encodes a precursor polypeptide that undergoes cell-specific proteolytic cleavage to generate -MSH (Toda et al

An obligatory component of the transfer process for fatty acids from the bloodstream into muscle mitochondria for use as fuel
