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Long term safety of these huge doses would need to be tracked

There is little research around the safety of milk thistle for pregnant or breastfeeding women so its best to avoid it under these circumstances

Ramel A, Wagner KH, Elmadfa I: Plasma antioxidants and lipid oxidation after submaximal resistance exercise in men

On the contrary, Japan, Korea, and other countries have established specialized approval systems for functional foods (e.g., FOSHU certification for Foods for Specific Health Uses), requiring the submission of sufficient scientific evidence to support health claims and implementing strict controls before and after marketing