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The filler contains lidocaine, which numbs the treated area
Noteworthy, in the Aloe vera juice used in the study by Metro et al

Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis

The interpretation of nail biopsies is difficult because punch biopsies, rather than longitudinal nail biopsies, are often performed and because in almost all specimens a degree of parakeratosis, spongiosis, and rare neutrophils are present
