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Over time, however, prolonged persistence under therapeutic pressure may increase the likelihood of genetic diversification and eventual acquisition of stable resistance mechanisms 13 , although the timing and molecular determinants of this transition remain to be further explored

Our results agree with findings from a previous study in California sea lions ( Zalophus californianus ) exposed to DA, where these authors found a significant association of DA exposure with reduced serum cortisol (Gulland et al., 2009), which can be tentatively attributed to abnormal function of the adrenal axis due to the exposure

doi: 10.1016/j.abb.2008.02.038

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