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No significant adverse effects were reported at any dose level tested, including the highest 1mg daily oral dose

Smith LK, He Y, Park JS, Bieri G, Snethlage CE, Lin K, et al

In corn, most nicotinic acid is bound, and the tryptophan content is low, thus making pellagra a likely outcome when corn is consumed as a staple grain without alkaline processing

Tirzepatide goes up to 15mg, and many people experience renewed weight loss at higher doses
