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In senescence, microglia and macroglia acquire a state of chronic activation that results in an autoimmune response, neuroinflammation and altered BRB, ultimately leading to neurodegeneration (Xu et al., 2009

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458 Therefore, hypermethylation of genes that promote cell entry into the G2/M phase can lead to radioresistance, such as hypermethylation of promoter site of the RPRM, which promotes radioresistance in nasopharyngeal carcinoma (NPC) cells

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