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RAS affects a large proportion of the population and has a point prevalence of approximately 23%, daily

When intracellular GSH levels decrease, GPX4 activity declines, allowing lipid peroxides to accumulate

86-88 Interestingly, individuals with depression also appear to have a greater likelihood of developing chronic pain syndromes, suggesting bi-directionality due to a common mechanism, possibly rooted in chronic or extreme stress and reduced neuroplasticity