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Although KD has shown therapeutic potential in these diseases, heterogeneity has shown varied results in KD therapy for specific disease subtypes, the clear mechanisms of which are still largely unknown

[DOI] [PubMed] [Google Scholar] 40.Reedy J., Lerman J.L., Krebs-Smith S.M., Kirkpatrick S.I., Pannucci T., Wilson M.M., Subar A.F., Kahle L.L., Tooze J.A

Solche Konjugationen werden durch (meist zytoplasmatische) Transferasen vermittelt und nutzen Glucuronat via (Uridindiphosphat--) Glucuronyltransferasen (UDP-GT) ( Abbildung), die sich (ausnahmsweise) im endoplasmatischem Retikulum befinden (so wie die Phase 1-Enzyme)

In AD, overexpression of HSP27 has been observed to improve neuronal excitability and reduce A plaque formation in animal models, suggesting a neuroprotective role (48)