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hydropiper L extract improved phosphorylation of AMPK (AMP-activated Protein Kinase ) that was reduced by lipopolysaccharide and decreased the generation of cytokines associated with inflammation, NO, and ROS protein expression of COX-2 (cyclooxygenase), iNOS (inducible nitric oxide synthase), and phosphorylation of c-JUN (N-terminal kinases), JNK, ERK, and MAPKs (mitogen-activated protein kinase)

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These MAPKs, including ERK and JNK, are serine/threonine protein kinases that regulate cell proliferation, differentiation, and apoptosis in tumorigenesis

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