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A recent metanalysis and systematic review described, based on observational studies, the association between LDLox concentrations and the development of atherosclerotic disease [46]

248 In smokers, whom have been proven in multiple studies to have low blood levels of vitamin C, oral supplementation with 2 grams vitamin C per day has been shown to significantly decrease urinary isoprostanes, 249 markers of oxidative stress, and monocyte adhesion to the endothelial lining of blood vessels, one of the early stages in the development of dangerous atherosclerotic plaque

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treatment, as one of the leading defense mechanisms under heat stress