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doi: 10.1053/j.gastro.2019.11.312 5
a validated isotope dilution LC-MS/MS assay capable of measuring Hb and HbA1c concentrations in individual erythrocytes

Graber JJ, Sherman FT, Kaufmann H, Kolodny EH, Sathe S

Furthermore, impaired cerebral metabolism appears to be an early-stage biomarker for ADRD, as several studies have shown reduced glucose metabolism in the hippocampus and posterior cingulate prior to observation of overt clinical symptoms (i.e., cognitive impairment) (Kumar et al., 2022
