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Think of an arthritic joint as a small ecosystem that has been thrown completely out of balance

RVT-1401, A novel anti-FcRn monoclonal antibody, is well tolerated in healthy subjects and reduces plasma IgG following subcutaneous or intravenous administration (P52079)

When it becomes oxidized, it can break down yielding a large variety of compounds including a, -unsaturated aldehydes (Poli et al., 1987) These are toxic compounds because they can react with proteins in the cells, particularly at cysteine, lysine or histidine by either Michael addition to the carboncarbon double bond or by Schiff base formation at the carbonoxygen double bond (Esterbauer et al., 1991

Because there are so few human studies, we do not have a clear picture of long-term safety