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Nonetheless, mice with constitutive mTORC1 activity in the liver, via TSC1 deletion, display decreased AKT phosphorylation and subsequently decreased phosphorylation of FOXO1 (329, 354)

Wang DT, Yin Y, Yang YJ, Lv PJ, Shi Y, Lu L, Wei LB

These effects were mediated by IL-33 and IL-25, which were not examined in the present study

The effects are generally not immediate and may take some time to become apparent
