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Niess et al
A subsequent trial with similar design, administering 24 IU IN-OXT or placebo in GSAD patients and healthy matched controls [191,192], found that IN-OXT enhanced functional connectivity between the amygdala, bilateral insula, and middle cingulate/dorsal anterior cingulate gyrus in response to fearful faces, in individuals with GSAD only [191]
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The results of pharmacokinetic analyses performed in normal volunteers show that following 4 mg SC, a peak plasma level 3 ng/mL (2.4 nmol/L) was obtained with a terminal half-life of 20 min (21)
