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One proposed mechanism is that lactate enhances hippocampal neuronal firing, potentially contributing to panic symptoms ( Holdemanella has been associated with reduced right amygdala and hippocampal volumes (Wanapaisan et al., 2022) brain regions consistently reduced in PTSD individuals ( Additional population studies have expanded these findings

Thioredoxin (Trx), present in the cytosol as Trx1 and in mitochondria as Trx2, is oxidized and upregulated in response to oxidative stress and elevated ROS levels

[DOI] [PubMed] [Google Scholar] 62.Drmic D., Kolenc D., Ilic S., Bauk L., Sever M., Zenko Sever A., Luetic K., Suran J., Seiwerth S., Sikiric P

Epithelial-to-mesenchymal transition and ovarian tumor progression induced by tissue transglutaminase