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Additionally, RSK phosphorylates the Thr265 site of pro-caspase-8, and low extracellular pH inhibits RIPK1 kinase activity

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All experimental procedures were carried out in accordance with the National Institutes of Health (NIH) guidelines for the Care and Use of Laboratory Animals, the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines, and were approved by the "Unit of Research Ethics Approval Committee, Pharos University in Alexandria" (PUA-01202104061021)