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In this light, we focus on one of the complications of chronically uncontrolled hyperglycemia: end-stage kidney disease, which necessitates kidney replacement therapy

These alterations contribute to systemic inflammation by increasing the production of pro-inflammatory cytokines, including interleukin (IL)-1, IL-6, IL-8, IL-13, tumor necrosis factor-alpha (TNF-), and transforming growth factor-beta 1 (TGF-1) [24]

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However, hydropersulfides are superior to -tocopherol owing to their low H-bond acidity, a unique attribute of hydropersulfides, which makes their reactivity largely insensitive to changes in the surrounding medium 20