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Furthermore, the threshold effect is consistent with the concept that methionine synthase activity may become saturated beyond a certain B12 concentration [17], explaining the diminishing returns observed at higher levels

doi: 10.1073/pnas.0509937103

However, having in mind its limitations and lack of current knowledge considering the probable mechanism of Ni toxicity, especially regarding its endocrine effects, further investigation is needed

This once-weekly cadence is one of the practical advantages of the long half-life: a single anchored injection covers the entire week, and there is no daily-dosing burden to maintain