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A multimodal approach to pain management may optimize the treatment of chronic pain, as well as assist with the successful tapering of the opioid analgesic (see WARNINGS, Withdrawal and DRUG ABUSE AND DEPENDENCE)
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Consequently, PKC phosphorylates the NOX2 cytoplasmic subunit (p47/Phox), causing a conformational change that enables its association with the NOX2 plasma membrane subunits, thus restoring the functionality of the NOX2 complex [96]
