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administered antibodies into the draining LN was observed earlier in a few experiments using sophisticated immunization protocols and adoptive transfer of lymphocytes, high doses (2025 g) of antifollicular DC antibodies, and extensive redistribution durations (2448 hours), but the pathways involved were not analyzed (50, 51)

DOI: 10.1089/ars.2009.2701 61

Reactions in the RECON model were identified and filtered for those with meaningful metabolic impact