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However, the largest 24-week trial with 536 participants failed to show statistically significant weight loss, which led to development termination

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675,676,677,678,679,680,681 These studies have implicated that GITR agonists alone could not reactivate the cytolytic function of T cells in tumor environment, and combinatorial approaches of GITR agonism and other immunomodulatory therapies are of great interest