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The authors showed how QU preserves the integrity of the endothelium barrier, enhances bloodlabyrinth barrier (BLB) permeability, inhibits CP-induced oxidative stress, protects mitochondrial function, lowers the apoptotic mitochondrial pathway of the PCs, and activates the PI3K/AKT signaling pathway

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Newer strategies to address these drawbacks like combination therapy (use of structurally different chelating agents) or co-administration of antioxidants have been reported recently

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Griffiths KK, Wang A, Wang L, Tracey M, Kleiner G, Quinzii CM, et al

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