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Description
At the lysosomal membrane, CMA inhibition occurs due to the AKT-dependent phosphorylation of the CMA regulatory factor glial fibrillary acidic protein (GFAP)
Because cartilage lacks blood vessels, it receives nutrients through diffusion, which limits its ability to repair itself
RSC Adv 5:27986

doi: 10.3389/fphar.2023.1295096 7 AnandP.ElsafaE.PriviteraR.NaidooK.YiangouY.DonatienP.et al
