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176,177 When GLP-1 binds to GLP-1R, it triggers the activation of G-proteins, leading to an increase in the intracellular second messenger cAMP

GSH scavenges a wide range of ROS ( OH, H 2 O 2 , 1 O 2 ), and due to the very low value of electron reduction potential of the GSSG/GSH redox couple ( E = 264 mV at pH = 7.4) is GSH able to regenerate several important antioxidants, such as radicals of vitamins E and C back to their active non-radical forms (Jones 2002) (Fig

Glyoxalase (Glo) performs conjugation of GSH with the glycolysis byproduct methylglyoxal to form (S)-lactoylglutathione (Figure 2)

However, it also includes naloxone, which deters misuse by blocking the euphoric effects of opioids when taken improperly