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The Arabidopsis mutant of Complex I ( ndufs4 ) with low phosphorylation efficiency has elevated AsA synthesis (Meyer et al., 2009)
As PER is translated in the cytoplasm, it is actively phosphorylated by DBT (casein kinase 1) and casein kinase 2 (synthesized by And and Tik ) as a prelude to premature degradation
It argues for a strategic shift in therapeutic development, advocating for the repurposing and adaptation of neuroprotective, anti-inflammatory, and redox-modulating strategies proven or proposed in AD, PD, and other neurodegenerative diseases
