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It is on this basis of such duality that the therapeutic context, whether one wishes to inhibit or induce pathological angiogenesis in tumors or reparative angiogenesis in degenerative diseases must be defined before a therapeutic can be applied in a clinical patient
High glucose-induced senescence contributes to tubular epithelial cell damage in diabetic nephropathy
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When transitioning between them , matching the appropriate dose level prevents both under-treatment and excessive side effects during the changeover period
