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[PMC free article] [PubMed] [Google Scholar] 94.Takei G.L., Mukai C., Okuno M

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In DFO-treated parasites, while some overlap with DHA-induced genes (e.g., merozoite-related functions) was observed at later stages, unique transcriptional changes were also evident, such as upregulation of genes involved in chromatin organization, protein-DNA complex assembly, nucleosome dynamics, regulation of RNA polymerase II-mediated transcription initiation, and regulation of protein catabolic processes

Studies have further demonstrated that macrophages are rapidly activated by the complement system during muscle injury, particularly through the complement activation molecule complement component 3a (C3a)