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Clinical practice suggests that antithyroid drugs combined with -adrenergic receptor antagonists can be used as effective drugs for the treatment of mental disorders and psychiatric symptoms caused by hyperthyroidism, as the excessive activation of the adrenal system induced by hyperthyroidism can lead to somatic symptoms ( Additionally, psychosomatic synchronization therapy is considered to be suitable for GD patients with psychiatric symptoms (185), as research has shown that the combination of antithyroid, antipsychotic drugs and psychotherapy contribute to the prognosis of the disease (186)

Historical Context and Treatment Before effective treatment, PA was often fatalhence pernicious. Breakthroughs (including Nobel Prize-winning work) led to liver therapy in the 1920s and injectable B12 after WWII

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Even though it is not always possible to distinguish between activity of GHK peptide and its copper complex GHK-Cu, we strongly believe that for the future therapeutical applications GHK-Cu should be used