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Research applications Research applications Investigation of FOXO4p53 interaction disruption and downstream apoptotic signaling In vitro studies of cellular senescence, senolysis, and age-related cell clearance Combination studies with chemotherapeutics, targeted agents, or senolytic compounds Mechanistic assays of apoptosis markers, mitochondrial dysfunction, and cell viability For laboratory research use only

Juraschek, S

289 Additionally, as sentinel cells in the central nervous system, microglia upregulate the expression of insulin-like growth factor-binding protein 6 (IGFBP6) in response to lactate, thereby promoting M2 polarization and recruitment of microglia in the zebrafish GBM model