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Specifically, AST suppresses the expression of lncITPF by inhibiting the phosphorylation and nuclear translocation of Smad3, thereby reducing the expression of its target gene ITGBL1

Nonphysiological gynecomastia can be pathologic, pharmacologic, or idiopathic in nature

For example, receptor pathway literature may describe GH-related signaling models, but a product page should not translate that into product effects or product performance language

10.1016/j.patbio.2014.05.015 Pathol