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Description
Dopamine was first synthesized in 1910, and initial studies examined its biologic effect as a weak sympathomimetic,although the mechanism of action was not clear (Barger and Dale, 1910)
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Interestingly, while hormones and sEV are chemically distinct, it appears that they play pivotal roles in intercellular information transmission [15]
TLS are organized clusters of immune cells that form near tumors and play a crucial role in coordinating antitumor immunity
