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When considering KD for MD the high rate of adverse effects should be taken into account, but also spectacular improvements in individual cases

[PUBMED Abstract] Winter SS, Dunsmore KP, Devidas M, et al.: Improved Survival for Children and Young Adults With T-Lineage Acute Lymphoblastic Leukemia: Results From the Children's Oncology Group AALL0434 Methotrexate Randomization

Methotrexate, heparin and insulin are all automatically given to patients to self inject at home, but all these are medications which need strict control, in contrast B12 injections (hydroxocobalamin) cannot be overdosed

Finally, although antioxidant supplementation is a promising strategy to mitigate oxidative damage in oocytes, the translational strength of evidence varies considerably across compounds, and this review advocates for a careful evaluation
