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In the amygdala, an upregulation of orexin expression has been associated with depression, while exercise-induced suppression of orexin in this region exerts antidepressant effects [136, 137]
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For the GLCM parameters, degenerative processes reduce the hypoechoic appearance of the interior of nerve fascicles compared with the hyperechoic surrounding structuresi.e., diminished interfascicular connectivity 58, 69
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