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The baseline lower GSH content in aged samples has been observed in many other tissues and is an example of age-related changes in glutamate catabolism

J Parkinsons Dis 2018;8:195-215

Interestingly, it has recently been shown that the indole-GSL breakdown products indole-3-acetonitrile (IAN) and indole-3-carbinol (I3C), although not structurally related to ITCs, are able to attenuate PCD induced by the mycotoxin fumonisin B1 [168]