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This autoimmune response leads to inflammation and destruction of the beta cells, resulting in a significant reduction or complete cessation of insulin production
Additionally, the nitric oxide radical (NO ) is enzymatically synthesized from the oxidation of arginine to citrulline by nitric oxide synthase (NOS) (Hajam et al., 2022)
It is likely that the addition of external CYP2E1 load into an in vitro system will exacerbate CYP2E1-mediated toxicity in U1 cells
These cells are found in the gastric glands, and parietal cells secrete intrinsic factor and hydrochloric acid (stomach acid)
