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Notably, omniligase-1, a broad-specificity ligase engineered from subtilisin BPN, was successfully used to synthesize exenatide, and peptiligase has been applied for gram-scale quantities of therapeutic peptides such as thymosin-1, exenatide, and the kalata B1 variant T20K

Chapter 36: Megaloblastic anemias: disorders of impaired DNA synthesis by Ralph Carmel "George H

It significantly downregulates the expression of CHS1 and alters the expression profile of other chitin synthase genes, leading to impaired chitin biosynthesis and subsequent cell wall damage in Candida albicans ( Guo et al., 2008