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doi: 10.1038/nrneph.2013.98

& Iyer, N

Although not much is known about these enzymes in cancer, the CHAC2 isoform has already been classified as a tumour suppressor gene in gastric and colorectal cancer, on the basis of its downregulation being associated with more aggressive cancer variants and its activation-inducing apoptosis in cancer cells

On the other hand, ethanols effects on glutamate, the principal excitatory neurotransmitter, are equally significant
