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doi: 10.3390/jcm11195741 98 ItoHIguchiAHatanoT

To gain insight into the dynamic changes in the tumor microenvironment of non-small cell lung cancer patients following neoadjuvant chemoimmunotherapy, we conducted comprehensive and in-depth single-cell RNA sequencing and spatial transcriptome sequencing on tumor tissue samples from a cohort of 12 NSCLC patients who underwent surgically resection of the tumors in our center

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In the proposed mechanism, xylitol induces Bip and CHAC1, resulting in decreased cellular GSH levels, ER stress, and ultimately apoptotic cell death