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Similarly high incidence has been recently reported in Chinese provinces south of the Yangtze River (Figure 2), including Guangdong, Fujian, Hunan, Shanghai and Xuzhou in Zhejiang.7-10 In fact, the highest incidence of CUD may be in Fujian at around 1 in 10,000 newborns.9 On the other hand, incidence was lower in Northern China, like Shangdong.11 The high disease incidence in this locality is due to common mutations