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Similarly, PM2.5-induced increased ROS levels result in ESC cytotoxicity [278], while high osmotic stress mediated H 2 O 2 /O/OH accumulation contribuites to ESC reprogramming [279]
In the mitochondria, the production of acetate from acetaldehyde leads to increased levels of acetyl-CoA
doi: 10.1016/s0006-2952(97)00254-2
That means therapies built on years of rigorous, double-blind, placebo-controlled human trials
