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Studies on human aortic endothelial cells (Table 3) showed that CBD reduced phosphorylation of c-Jun N-terminal kinase (JNK), nuclear factor B (NF-B), ribosomal protein S6 kinase (p70S6K) and signal transducer and activator of transcription 5 (STAT5), and increased phosphorylation of cAMP response element - binding protein (CREB), extracellular signal - regulated kinase 1/2 ( ERK1/2), protein kinase B (Akt) and endothelial nitric oxide synthase (NOS)

[Crossref] Nyholm E, Turpin P, Swain D, Cunningham B, Daly S, et al

Recent, double-blind and comparative research has shown that topical tranexamic acid in amounts between 2-5% rivals results of over-the-counter amounts of hydroquinone, long considered the gold standard for fading skin discolorations

1a and Table 2)